Anesthesia is the loss of sensation. Anesthetic agents are drug used to to achieve anesthesia. Anesthesia allow patients to undergo surgery and other procedures without distress and pain they would otherwise experience.
There are 4 aspects in the practice of surgical anesthesia i.e:
1. Pre-anesthetic
2. Induction
3. Maintenance
4. Recovery
Anesthesia result from an effective anesthetic tension (concentration in partial pressure) in the brain. The faster the induction, the faster the effective anesthetic tension in the brain is achieved.
Distribution of anaesthetic to the tissue ( rate of rise of anesthetic tension in any tissue) depends on tissue solubility of anesthetic and tissue perfusion.
1.Tissue solubility
Tissue solubility of anesthetic is expressed as tissue blood perfusion coefficients which value usually 1-3 for most tissue but >>>1 for fat. The higher the the tissue solubility, the higher the time to reach equilibrium between tissue and arterial blood and thus the slower is the rate of increase in anesthetic tension.
2. Tissue perfusion
Fat is poorly perfused tissue. So equilibrium with fat (6% of cardiac output) is the slowest.
Thus, in person with high fat content (fat people), tissue solubility of anaesthetic is higher and tissue perfusion is lower. So it take more time to equilibrate and reach effective anaesthetic tension.
I post this as a reply of request from my friend who ask about the influence of fat on anesthesia in fat people. Do correct me if u find that my conclusion is not correct.
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