Panadol ActiFast Versus Panadol Regular

What is the difference between this 2 products?

Panadol regular or panadol 500mg. Each tablet contain 500mg of paracetamol. The price is around RM 2.80 for 10 tablets.

Panadol ActiFast. Each caplet contain 500mg of paracetamol + 173mg of sodium. The price is around RM 4.60 for 8 caplets.

The amount of active ingredient is the same. So what is the difference between this two products? 

The key different actually lies in the excipient (non-active ingredients content of the tablet).

 For the drug to carry out it action, it must be absorbed from our gastrointestinal tract (GIT). Paracetamol is poorly absorbed in the stomach but well absorbed in the small intestine due to the greater surface area and hence absorptive capacity of the small intestine. 

Sodium bicarbonate is an excipient in the formulation which has a role in increasing the rates of gastric emptying (hence movement of drugs from the stomach into small intestine) and that of dissolution and hence the speed of absorption of paracetamol to provide faster onset of relief.

However, the amount of sodium bicarbonate in 2 tablets of Panadol ActiFast are required per dose to have such an effect which mean you have to take 2 tablets of Panadol Actifast to has that fast rate of absorption.

The rate of absorption of Panadol ActiFast is twice as fast as standard panadol if taken in 2 tablets per dose.

If you take only 1 tablet of Panadol Actifast, the rate of absorption is the same as taking 1 tablet of standard panadol. For asian, it is customary that sometime we take only 500mg (1 tablet) of doses. So I would suggest to take standard panadol if you wish to take only 1 tablet as it would be cheaper while the effect is the same.

The extend (amount) of drug absorption is the same for both product. The Panadol ActiFast is meant to give fast relief of pain while the EFFICACY of both product is the SAME 

Reference:

1.GlaxoSmithKline Consumer Healthcare. Retrieved from: http://www.medicines.org.uk/emc/medicine/21529/SPC/panadol%20actifast/

2, Drugs.com. Panadol ActiFast. Retrieved from: http://www.drugs.com/uk/panadol-actifast-spc-8801.html

Hypocrite!!

Korang pernah tak jumpa orang yg cakap "i hate hypocrite!", "aku benci gila kat org yg hipocrite!" dan ayat2 yg sewaktu dengannya atau adakah anda tergolong dalam golongan yg macam ni? If u r one of this people then u r a bigger hypocrite!!!!

Because for me, most of us used to be hypocrite, it just the matter of how u define that word. Just take at look at this few definitions of hypocrite!!!! :

1. A person who engage in the same behaviors he condemn others for.

2. A person who profess certain ideals, but fail to live up to them.

3. Someone who complains about something but find themselves doing exactly the same thing.
 A: "i hate people that complain about other people, they're SO annoying!"
B: Shut up, hypocrite!


4. Someone who say they would never do something or never be like someone, yet turns around and does the thing that they say they will never do.

5.Someone who say they hate something but when someone else says they like it, they turn around and say they like it too. (A follower)

source: urban dictionary


Having read the definitions stated above, are u sure u never belong to any of the categories above? Come on la, how many time u have smile to the people that u dont like?

How many time u have being nice in front of someone but u condemn the person behind their back? Isnt that hypocrite??

You hate when people cheat you but it is ok for u to cheat.

How many time u have been trying to be nice to a person and conceal ur bad behavior??

U preach something that u dont do. Isnt that hypocrite?

I am a hypocrite and i treat different people differently and i did that for some reason but i hate someone who say they hate hypocrite and condemn me for being one!

QUote

 I sit on a man's back, choking him and making him carry me, and yet assure myself and others that I am very sorry for him and wish to ease his lot by all possible means -- except by getting off his back. -leo tolstoy

Time

"It's sad when people you know become people you knew..when you can walk past someone like they were never a big part of your life..how u use to be able to talk for hours and how can barely even look at them..its sad, how time change.."

F.r.i.e.n.d

When i finished working today, i switched on my phone and i received a msg from my colleague back then in matriculation.

The msg is:

"We never know the true value of friends. While they live, we r too sensible of their faults. When we have lost them, we see only their virtues. Thus we cannot get much out of friendship unless we r ready to forgive each other weaknesses. Friends 4ver."

This is the msg which i used to sent to a friend of mine which r having conflict with my best friend.

p/s: the person who sent the msg r not in this pict

Histamine

Histamine is the ligand for 2 membrane-bound receptors i.e the H1 and H2 receptors which are present on many cell types.

The activation of H1 histamine receptors on the endothelial and smooth muscle cells leads to increase in capillary permeability.

The activation of H2 histamine receptors lead to arteriolar and venules vasodilation. This causes extravasion of the fluid and causes the areas involved to be inflammed.

Choices

Last night while chatting with a friend. She told me something that made me think...

"Family is the choice Allah made for me while Friend is something that i choose"

I love my family but i think i have prioritize my friends far more than my family.

My family