Histamine is the ligand for 2 membrane-bound receptors i.e the H1 and H2 receptors which are present on many cell types.
The activation of H1 histamine receptors on the endothelial and smooth muscle cells leads to increase in capillary permeability.
The activation of H2 histamine receptors lead to arteriolar and venules vasodilation. This causes extravasion of the fluid and causes the areas involved to be inflammed.
No comments:
Post a Comment